Immunospecific immunoglobulins and IL-10 as markers forTrypanosoma brucei rhodesienselate stage disease in experimentally infected vervet monkeys
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منابع مشابه
IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense
The management of human African trypanosomiasis (HAT) is constrained by lack of simple-to-use diagnostic, staging, and treatment tools. The search for novel biomarkers is, therefore, essential in the fight against HAT. The current study aimed at investigating the potential of IL-6 as an adjunct parameter for HAT stage determination in vervet monkey model. Four adult vervet monkeys (Chlorocebus ...
متن کاملParasitaemia in Rabbit Bucks Experimentally Infected with Trypanosoma Brucei Brucei
This study was designed to determine the levels of parasitaemia on 20 healthy domesticated rabbit bucks infected with Trypanosoma brucei brucei over a period of eight weeks. Ten out of the 20 bucks were infected with 1 ml of the parasite containing 1 X 10 trypanosomes and known as infected group A, while the remaining ten bucks were left uninfected as group B. The infected bucks were monitored ...
متن کاملWild Vervet Monkeys Trade Tolerance and Specific Coalitionary Support for Grooming in Experimentally Induced Conflicts
Grooming is a key social behavior in many primate species. Research has focused on three important aspects: the short- and long-term trading patterns of grooming for itself and/or for other commodities like tolerance or coalitionary support, the issue of whether exchanges are a convincing example for reciprocity, and what decision rules underlie trading. These issues remain largely unresolved d...
متن کاملDevelopment of a safer laboratory vervet monkey model for the study of human African trypanosomiasis
BACKGROUND There are three subspecies of Trypanosoma brucei: T. b. gambiense, T. b. rhodesiense and T. b. brucei. The first two are infectious to humans, whilst T. b. brucei is not. Identifying an animal model of T. b. brucei that mimics human African trypanosomiasis (HAT) would enable researchers to study HAT without subjecting themselves to undue risks such as accidental infection. OBJECTIV...
متن کاملTrypanosoma brucei rhodesiense Transmitted by a Single Tsetse Fly Bite in Vervet Monkeys as a Model of Human African Trypanosomiasis
We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys. Tsetse flies were confirmed to have mature trypanosome infections by xenodiagnosis, after which nine monkeys were infected via the bite of a single infected fly. Chancres developed in five of the nine (55.6%) monkeys within 4 to 8 days post infec...
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ژورنال
عنوان ژورنال: Tropical Medicine & International Health
سال: 2009
ISSN: 1360-2276,1365-3156
DOI: 10.1111/j.1365-3156.2009.02285.x